The study aims to examine the link between social innovation (SI) and sustainable entrepreneurship (SE). The major focus is to explore how SI is promoted by the SE and what the Sustainable Development Goals (SDGs) are covered by the sustainable entrepreneurship through promoting social innovation identified through a research gap by adopting the TCCM framework. The study is a systematic literature review on the publications in the Scopus database identified through keywords relevant to the theme by adopting the SPAR-4-SLR protocol. The result indicates that the sustainable entrepreneurs promoting SI innovation through innovative business models ensure social well-being. The SI is not only the technological but also non-technological aspects, which are responsible and impactful, having innovative approaches, social practices, and processes. The SEs are developing business models that are socially and sustainability purpose-driven, offering financial advantage and ensuring the social cohesion and the empowerment of the community through their participatory approaches and ensuring the local level stakeholders’ engagement. SE develops partnerships and collaboration among the different actors, which will create knowledge sharing and collaborative innovation. While mapping of SDGs to SI by SEs, the study identifies that the major SDGs covered are: SDG 1, SDG 4, SDG 5, SDG 8, SDG 9, SDG 10, etc. The study offers implications to practitioners, policymakers for actionable strategies to enhance the SI-driven SE ecosystem. This systematic review lacks empirical findings and relies purely on the published works. The limitations will open future research scope avenues by covering more databases, keywords, etc.