In recent years, an intense dialogue has developed around multimodal tourism due to the various benefits it brings at a social, economic, political, religious, cultural, environmental, national, and even international level. Multimodal tourism refers to a form of tourism in which the combination of tourism skills that can be developed in an area is sought. The aim of the current chapter is to propose potential multimodal tourist routes in Greece, highlighting how such routes can support sustainable destination development. Potential routes are identified using GIS mapping, network and path analysis, tourism sustainability assessments, and qualitative stakeholder research. The design of these routes varies according to geography and thematic focus—such as history, nature, gastronomy, or adventure—shaped both by visitor interests and local community offerings. This research attempts to integrate these diverse preferences while emphasizing authenticity, quality, and sustainability as key elements for long-term viability. Multimodal planning considers the distinct characteristics of each area, including its economy, workforce, and cultural identity. The study concludes that multimodal tourist routes can serve as strategic tools for local development and destination branding. This research is especially relevant to regional planners, tourism developers, local governments, and policymakers aiming to promote diversified and sustainable tourism models in underutilized regions.