Plant–microbe interactions play a substantial role in improving plant health. Among plant–microbe interaction researches, plant growth-promoting rhizobacteria (PGPR) are extensively researched microbial group that exerts beneficial effects on plant growth by synthesizing phytohormones, hydrogen cyanide, and siderophores as well as by increasing the bioavailability of nutrients. Several PGPR traits can enhance plants’ stress tolerance against heavy metal stress, salinity, and drought stress, among others, by employing a specific defence mechanism referred to as induced systemic tolerance (IST). The IST is a natural phenomenon that allows plants to acclimatize to changing environmental situations. Thus, this chapter explores the current understanding of plant–microbe interactions, with a specific focus on PGPR and their involvement in amelioration of abiotic stresses. It also discusses how these interactions can be leveraged to IST in plants. This chapter will discuss how PGPR regulates plant physiology, stress responses, and the molecular signalling pathways involved in IST, as well as the potential implications of these interactions in sustainable agriculture and crop management. By examining the latest research in this rapidly evolving field, this chapter aims to provide future directions on how plant–microbe interactions can be harnessed to boost plant resilience to abiotic stress.