Education 5.0 is a new paradigm in education posing many challenges and opportunities. This paper uses qualitative methods to explore students’ and teachers’ experiences with online learning to understand the challenges, benefits, and vision for a successful blended learning model, proposing a dynamic framework for blended learning. Results of in-depth interviews show the three main challenges of blended learning: pedagogical design, technological design, and environment/ setup design. Finally, the study discusses insights into future directions for developing Education 5.0, including the need for ongoing research, collaboration communities, curricula personalization, and innovation in the field.