This chapter offers a brief overview of the current challenges to the implementation of patient-centered care (PCC) within the primary care (PC) settings. It presents the role of non-pharmacological interventions (NPI) in PCC and introduces concepts of culturally competent and contextualized care. The chapter also offers a brief introduction to the integrative medicine (IM) approach and highlights its key interventions. Finally, it overviews the goals and structure of the book.