With the ongoing digital intelligent transformation of museums, user needs have increasingly become the core driving force behind exhibition planning and cultural content design. From the perspective of participatory cultural theory, this paper explores the construction of a systematic relationship between user needs, cultural content, and technological approaches in the process of digital intelligent transformation of museums. Combining qualitative analysis and empirical research, the synergistic theoretical model of “User needs-Cultural content-Technological approaches” is derived, as well as the roles and impacts of key variables, to provide forward-looking and universal innovative strategies for the digital intelligent transformation of museums.