Urban greening can be considered one of the most important factors to be taken into consideration in enhancing microclimate conditions, as it affects temperature reduction, air quality improvement, and mitigation of urban heat island effects. This research study identifies sustainable landscaping strategies and suitable plant selection for Al Qarayen 1 area in Sharjah and its effect on microclimate enhancement through a comprehensive review of the literature. The findings of this study reveal the importance of selecting plant species that align with the area’s climate and spatial characteristics. Also, it showed the importance of integrating green areas, green roofs, vertical greening, and water bodies in enhancing the urban microclimate and reducing CO2 levels. Moreover, the findings highlight that in hot climates like the UAE, tall plants (10–12 m), cylindrical shape with high LAI, are more effective in enhancing the microclimate. Moreover, a tree coverage ratio of 30–35% can be considered ideal for this area with taking into consideration suitable spacing between the trees. Implementing these strategies is expected to reduce the air temperature by 1–2 °C compared to the no-vegetation scenario in the area. Also, the surface temperature can be decreased by 10–20 degrees under shade. Moreover, vegetation will have effects on the relative humidity in the area as it increases humidity through evapotranspiration. The results highlight the significant potential of urban landscaping to address microclimatic challenges, providing a replicable recommendation for sustainable urban development in hot climates.