Fungal infections pose a serious risk to human health, especially to those with weakened immune systems. Although fungi are common and difficult to treat, it might be challenging to manage these infections because there aren’t many antifungal medication options. Furthermore, these medications can cause fungus to develop drug resistance, making treatments less effective. Fungal nanosystems can be considered one of the most prospective research domains. These nanosystems employ nano-scaled particles extracted from or based on fungi for enhancing fungi for combating fungal infections due to its unique properties of fungal-based nanomaterials. These devices would be able to easily identify fungal cells, deliver antifungal medications to the scene, and enhance the host’s immune response. Furthermore, fungal-based nanosystems should eventually be able to help with the faster and more accurate identification of fungal infections. This book chapter aims to describe studies in which nanomaterials/nanosystems were synthesized using fungi as reducing agents, discussing the mechanisms and optimization of the synthesis, as well as the applications. The literature shows that various species of fungus have potential for use in biogenic synthesis, enabling the production of nanomaterials/nanosystems and this nanosystem is used for controlling fungal infection. Nanosystems/nanomaterials synthesized using fungi enable the control of fungal infection, with low toxicity and good biocompatibility. The potential applications of fungal-based nanosystems as fungal infection control solutions in the future. Fungal-based nanosystems, which build on current research trends, have the potential to become more effective in the fight against fungal infections in the future.