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The pharmacological treatment of Stage C heart failure is based on the pillars of guideline directed medical therapy. Despite clinical trials showing great mortality benefit with these medications, the quadruple therapy at target doses is still underutilized. Here we discuss the key clinical trials and recommendations for HFrEF treatment and the optimal way to initiate and up-titrate these medications in patients.

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Guideline Directed Medical Therapy and How to Get There

  • 章节

  • 发表日期：

    2026年

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  • Sawan Dutta,
  • Yevgeniy Brailovsky,
  • Indranee Rajapreyar

摘要

The pharmacological treatment of Stage C heart failure is based on the pillars of guideline directed medical therapy. Despite clinical trials showing great mortality benefit with these medications, the quadruple therapy at target doses is still underutilized. Here we discuss the key clinical trials and recommendations for HFrEF treatment and the optimal way to initiate and up-titrate these medications in patients.