Artificial intelligence (AI), the Internet of Things (IoT), and cyber-physical systems are some of the latest technologies that have transformed how businesses are conducted in the fast-changing world of Industry 5.0. Nevertheless, in parallel with these developments, the demand for effective data analytics, cybersecurity, and privacy protection is becoming crucial more than ever. Industry 5.0 does not only require the increased efficiency of the operation based on data-driven insights, but it also requires the protection of the immense volumes of sensitive data produced in a world that is becoming more and more interconnected. In this chapter, the authors explore the changing place of data analytics, the security issues of connected systems, privacy questions that occur when using personal data, and how to reduce these risks. With these issues tackled, businesses will be able to guarantee the safe and responsible adoption of Industry 5.0 technologies and make the most out of the potential offered by innovation and growth.