This chapter explores the strategic role of project management in healthcare as a transformative methodology for enhancing care delivery, operational efficiency, and patient outcomes. Drawing on the foundational principles of the Project Management Institute (PMI), the chapter details the structured lifecycle of project management—initiation, planning, execution, monitoring and controlling, and closing—and its evolution from industrial origins to a universal discipline. While rooted in traditional sectors such as construction and engineering, project management has become essential in healthcare, where complexity, interdependence, and unpredictability demand a tailored and adaptive approach. Through real-world examples, the chapter illustrates how hospitals and health systems apply these principles to implement electronic health records, optimize emergency departments, and redesign care pathways. Particular attention is given to stakeholder engagement, interdisciplinary coordination, and the integration of clinical logic into planning and risk management. Agile and hybrid frameworks are discussed in relation to the dynamic nature of healthcare projects, emphasizing iterative cycles, real-time problem-solving, and value-driven outcomes. The project manager’s role emerges as both technical and relational—requiring leadership, emotional intelligence, and strategic vision. Ultimately, the chapter positions project management not just as an operational tool but as a core competency for innovation and excellence in modern healthcare systems.