Severe burn injuries represent one of the most complex challenges in modern medicine, often requiring interdisciplinary management across intensive care, surgical reconstruction, infection control, and long-term rehabilitation. While early excision and grafting remain the cornerstone of acute surgical treatment, regenerative strategies are gaining increasing importance in improving both short- and long-term outcomes. This chapter explores the integration of regenerative medicine into the clinical management of complex burn injuries, with a particular focus on critically ill patients requiring intensive care. Regenerative medicine is not intended to replace surgical principles but to complement them—bridging the gap between life-saving intervention and tissue restoration. As research evolves, individualized regenerative concepts tailored to patient comorbidities, burn severity, and systemic response are likely to shape the future of burn care. This chapter provides a clinically grounded, forward-looking overview of regenerative strategies in complex burn treatment, aiming to support clinicians in evidence-based integration of innovative therapies into practice.