Wounds can be caused by trauma, surgical procedures, or other medical conditions. Skin wounds compromise barrier function, increasing susceptibility to bacterial and viral infections that often delay healing and worsen the condition. Bone marrow-derived cells play important roles in wound healing. Platelets aid in hemostasis, while leukocytes and macrophages defend against cytotoxins and pathogens. Bone marrow-derived hematopoietic stem/progenitor cells that survive this hyperacute phase form tissue-specific vascular, neural, and lymphatic niches and conduct spatiotemporal remodeling according to the site of wound development. However, in severe injuries beyond biological wound healing abilities, systemic diseases, such as diabetes and arteriosclerotic diseases, or aging, acute healing is delayed, leading to chronic inflammation and fibrosis, hindering full recovery. In this chapter, we elucidate the nerves, blood vessels, and lymphatic pathways linking the bone marrow and skin as a communication axis, highlighting the cellular and molecular signals exchanged between them. It emphasizes the role of bone marrow-derived stem/progenitor cells in skin repair and provides insights into the mechanisms and countermeasures of delayed wound healing in chronic disease conditions.