Perfectionism is strongly associated with psychopathology and poses challenges in psychotherapy, including strained alliances and resistance to change. This chapter explores the application of compassion-focused therapy (CFT) for perfectionism. From the perspective of the CFT model, perfectionism is conceptualised as a safety strategy formed in response to early attachment injuries and threatening environments, interwoven with self-criticism and fears of compassion. Through case formulation, psychoeducation, and experiential practices, CFT enables clients to position the “perfect self” as one aspect of multiple selves, creating space to cultivate a compassionate self and supporting integration. Recent case studies and outcome research suggest that CFT-based interventions are effective in reducing perfectionistic processes and enhancing well-being. The chapter further examines cultural influences, noting that self-oriented perfectionism tends to appear more often in independent contexts, whereas socially prescribed perfectionism is emphasised in interdependent ones. Processes such as self-disclosure and self-effacement are shaped by cultural norms and relational mobility, affecting both expression and therapeutic response. CFT’s relational orientation allows it to integrate Western and Eastern perspectives, offering a promising framework for cross-cultural clinical application.