Nutrigenomics is the science that explores the potential of interaction between genes and food. Every individual has different genes and health status, which gives a pathway to research in the field of nutrigenomics and integrating it into clinical practices. It provides an insight to analyze public health status and recommend well-balanced nutrition to maintain good health for long term. The science of nutrition and genomics plays a vital role in delaying the emergence of chronic disease by understanding the genetic factor and modifying the nutrient metabolic pathway. The contribution of nutrigenomics in the field of clinical nutrition and public health care is boundless. Nowadays, millions of people have become conscious of healthier eating habits and better lifestyles due to the fear of existentially serious health conditions like cancer and heart attacks. Increasing awareness for health and wellness evidently gives rise to adopt and research more on nutrigenomics endlessly. Nature-based green foods are essential for promoting optimal health due to their high nutritional value and numerous health benefits. Incorporating nature-based green foods into our diet and in clinical practice can have a significant impact on overall health and well-being of millions of people. The concept of nutrigenomics can be merged with natural green foods to provide a sustainable nutrition source to prevent illness and promote wellness. Hence, this chapter explores how the concepts of nutrition and genetics are interconnected, the nutrient-metabolic pathway, the role of nutrigenomics in clinical practices to improve public health status, and promoting natural green foods as healthy ingestion habits as an excellent choice to promote overall health and well-being.