Renowned for its massive masonry oval dome, the largest worldwide, the Sanctuary of Vicoforte has faced significant structural issues, including settlement and cracking. Since the 1980s, a sophisticated monitoring system has evolved, incorporating static and dynamic measurements, supported by geotechnical surveys. Recent advancements include the integration of satellite data. The collection and the analysis of these different kind of data aimed at developing a robust Digital Twin for real-time diagnostics and predictive analysis, paving the way for resilient management of architectural heritage. Temperature-induced behaviors, such as changes in vibration frequencies and crack dynamics, reveal complex interactions between environmental conditions and structural responses. Future upgrades will focus on further integrating remote sensing capabilities to enhance this innovative approach.