Diabetes mellitus (DM) is a major metabolic syndrome and accounts for about 2.8% of the population worldwide that are affected by any metabolic disease and is projected to rise to 4.4% by 2030. Sulfonylureas, biguanides, α-glucosidase inhibitors, thiazolidinediones, and non-sulfonylureas secretagogues are some of the categories of the drugs available in the market which works via improvement of insulin sensitivity, secretion, complementing insulin, and stimulating glucose uptake. The currently used drugs have been associated with several side effects such as hepatic failure, weight gain, tachycardia and hypothyroidism. Herbal drugs have been a source of cure for several diseases including DM. Herbal drugs have several advantages such as safety, ease in availability, less side effects and more economical in comparison to synthetic drugs. Euphorbia is one of the important medicinal plant of dicotyledons and phytoconstituents (flavanoids, terpenoids and tannins) obtained from this plant find use in the treatment of viral infections, rhinitis, spasms, asthma, and skin diseases, etc. This plant has been reported to have in vivo antidiabetic action but the exact mechanism of action of phytoconstituents of this plant is still unknown and is a matter of investigation. For this purpose docking studies on 3D structures of three proteins involved in type-2 DM viz., protein-tyrosine phosphatase 1B, α-Glucosidase and α-Amylasewere performed using known 25 phytoconstituents of this plant. The conclusion of the study is based on docking energies and availability of important amino acid interactions which sheds light on possible mechanism of phytoconstituents.