COVID-19 is an infectious disease caused by a novel corona virus SARS-CoV-2 strain (nCoV) and has become a deleterious issue around the globe since December 2019, prominently from Wuhan, China. Millions of lives were destroyed hampering the economy and social security. Even WHO declared it as a dreadful pandemic disease that negatively impacted human unity and pressured the brain to be bound under complete isolation and lock down. SARS-CoV-2 damages the lungs, heart, forced liver, and even neuronal vascular endothelium, resulting in brain fog, lethargy, and tremors. Although COVID-19 can cause a variety of extrapulmonary symptoms, the heart, brain, and kidneys are especially vulnerable. This vascular component of COVID-19 may contribute to the explanation of the brain fog that some people experience a few months after the virus has cleared. The global COVID-19 pandemic has baffled several scientists and researchers with its versatile consequences and behavior in the etiology of several diseased conditions in post-COVID patients. The indirect and direct negative impact of COVID-19 on memory and other cognitive brain fog in humans is now a major research arena in almost all countries. There hardly exists any allopathic medicine for the treatment of COVID-19-associated brain fog. The current investigation aims to investigate the pathophysiology of the disease and structure-based screening of natural compounds to combat the dreadful post-COVID symptoms of brain fog due to neuro-inflammation followed by degeneration. Thus, a person detected with SARS-CoV-2 infection can be dealt with naturopathy to help in the recovery of memory-loss-function and combat associated neurological complications.