The historical importance of Indian medicinal plants is well documented in traditional systems of medicine such as Ayurveda and Unani. These plants are renowned for their medicinal effects that enhance general well-being. With modern scientific progresses, there has been an increased interest in exploring the bioactivity of these plants to uncover the active compounds responsible for their pharmacological effects. This has given rise to a growing field of research focused on Indian medicinal plants, which extends beyond traditional practices to contemporary pharmaceutical breakthroughs. In this context, a manually curated database called BIMP (Bioactivity information of the phytochemicals of Indian Medicinal Plants) is introduced here. This database provides information on 105,909 Phytochemicals found in 6,209 Indian medicinal plants. It includes information on both known and predicted targets for the compounds, along with specifics on the diseases and the target genes/proteins with information of organisms. Additionally, the database assesses physicochemical properties and drug similarity using cheminformatics tools, aiding drug discovery efforts. Of the 105,909 Phytochemicals, 72,318 comply with at least one of the major drug-likeness rules. The BIMP database represents a significant advancement in facilitating in-silico drug discovery processes by providing a comprehensive platform for discovering the therapeutic potential of Indian medicinal plant components. It also offers a protocol for identifying targets and molecules, streamlining the drug discovery process. It is openly accessible and offers researchers a valuable database for advancing drug development based on natural products. Database URL: https://scfbio-iitd.res.in/bimp

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BIMP: Unveiling the Phytochemical Richness of Indian Medicinal Plants as Potential Therapeutic Agents

  • Dheeraj Kumar Chaurasia,
  • Raushan Anjum,
  • Aman Sharma,
  • Madhvi Mishra,
  • Shashank Shekhar,
  • Ashok Kumar Patel,
  • Aditya Mittal,
  • B. Jayaram

摘要

The historical importance of Indian medicinal plants is well documented in traditional systems of medicine such as Ayurveda and Unani. These plants are renowned for their medicinal effects that enhance general well-being. With modern scientific progresses, there has been an increased interest in exploring the bioactivity of these plants to uncover the active compounds responsible for their pharmacological effects. This has given rise to a growing field of research focused on Indian medicinal plants, which extends beyond traditional practices to contemporary pharmaceutical breakthroughs. In this context, a manually curated database called BIMP (Bioactivity information of the phytochemicals of Indian Medicinal Plants) is introduced here. This database provides information on 105,909 Phytochemicals found in 6,209 Indian medicinal plants. It includes information on both known and predicted targets for the compounds, along with specifics on the diseases and the target genes/proteins with information of organisms. Additionally, the database assesses physicochemical properties and drug similarity using cheminformatics tools, aiding drug discovery efforts. Of the 105,909 Phytochemicals, 72,318 comply with at least one of the major drug-likeness rules. The BIMP database represents a significant advancement in facilitating in-silico drug discovery processes by providing a comprehensive platform for discovering the therapeutic potential of Indian medicinal plant components. It also offers a protocol for identifying targets and molecules, streamlining the drug discovery process. It is openly accessible and offers researchers a valuable database for advancing drug development based on natural products. Database URL: https://scfbio-iitd.res.in/bimp