We initiate the study of quantum Interactive Oracle Proofs (qIOPs), a generalization of both quantum Probabilistically Checkable Proofs and quantum Interactive Proofs, as well as a quantum analogue of classical Interactive Oracle Proofs. In the model of quantum Interactive Oracle Proofs, we allow multiple rounds of quantum interaction between the quantum prover and the quantum verifier, but the verifier has limited access to quantum resources. This includes both queries to the prover’s messages and the complexity of the quantum circuits applied by the verifier. The question of whether QMA admits a quantum interactive oracle proof system is a relaxation of the quantum PCP Conjecture. We show the following two main constructions of qIOPs, both of which are unconditional: As a key component of our construction, we introduce a novel single prover many-qubits tests, which may be of independent interest.