Climatic variables such as temperature, humidity, and precipitation significantly influence the distribution of TBDs. Changes in the seasonal activity of ticks, tick genotype, tick development rate, and geographical distribution are important indicators of the impact of climate change on ticks and TBDs. Ecological factors such as deforestation and habitat fragmentation also lead to climate change which ultimately influences the distribution patterns of ticks. Ticks also cause zoonotic TBDs which highlights the importance of understanding the epidemiology and distribution patterns of ticks. Climate-based models have been developed to observe the effect of climate on different TBDs along with recording the geographical distribution of ticks. Different research has indicated that the incidence of Lyme disease has been increasing in different regions of the world such as Europe and North America. Socioeconomic factors play an important role in regulating the transmission of TBDs. Important socioeconomic factors include deforestation, educational index, unemployment, and recreation. Differentiating the effect of climate on the distribution of ticks from other factors such as the host population will help us to design the control strategies for TBDs more effectively.