Flooding is one of the most destructive hydro meteorological disasters worldwide, leading to loss of life, damage to property and infrastructure. To help reduce these risks, it is important to identify and visually map areas at risk of flooding. This study focuses on a local-level flood risk assessment for the Lower Indus River, using a new spatial analysis approach. The research utilized the Hydrologic Engineering Centre’s River Analysis System (HEC-RAS) within a geographic information system (GIS) to analyze flood risks. It also used data from Advanced Land Observing Satellite Phased Array type L-band Synthetic Aperture Radar ALOS PALSAR satellite to map the region and create a model of the river’s shape. Hydraulic and hydrological data were applied to predict and visualize the vertical profile and spatial extent of different flood scenarios in the active floodplain of the Indus River. Spatial hydrological modeling is applied to assess the risk of Sukkur Barrage breach for different scenarios which results in maximum spatial extent (24.5 km) and vertical profile (11 m). Analysis revealed that likelihood of such flood has increased the risk of potential damages to agricultural land (1.9 million acres), built up area (625 km2), bridges (4) and barrages (2). The simulated result shows that about 23%, 74%, 76%, 77% houses will be inundated for the 25%, 50%, 75% and 100% breaches respectively. The findings offer valuable insights for disaster managers, hydraulic engineers, and policymakers, aiding in a better understanding of flood risks and the implementation of targeted, effective risk mitigation strategies.