The global energy transition and decarbonization trends are having a significant impact on the global air transportation market. In the context of increased turbulence and the tendency towards fragmentation of the contemporary global economy, it seems quite timely to analyze the possibilities of using smart transport systems by airlines in the context of digital transformation. The annual reports of airlines and the Statista portal served as sources of data for the analysis. The global air transportation market is influenced by many different factors. In the research, the authors classified these factors, distributed them into groups by relevance, and assessed their impact on the global air transportation market during global turbulence. Using a multiple linear regression model, the authors analyzed the degree of influence of several factors on international air transportation, which made it possible to identify the most and least important influencing factors. External factors had a greater influence on airline net profits than internal ones (i.e., qualitative factors outweighed quantitative ones). Based on the findings of this research, the authors established a direction for future research into the impact of various factors on the global air transportation market.