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We present technological advances in Digital Holographic Microscopy (DHM) enabling the acquisition of quantitative phase signals virtually free of coherent noise. This is achieved through a polychromatic implementation (p-DHM) that combines multi-wavelength acquisition with advanced signal processing. The resulting high-fidelity phase data reveal subtle dynamic and structural cellular processes. When applied to patient-derived cells, this methodology enables the identification of disease-specific phenotypes, opening new perspectives for diagnostics, mechanistic insight, and drug screening.

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Unlocking Disease-Specific Biomarkers: Digital Holographic Microscopy and Human Cells in Concert

  • 会议论文

  • 发表日期：

    2026年

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  • C. Larivière Loiselle,
  • M. Haouat,
  • C. Soubeiran,
  • M. Moreaud,
  • E. Bélanger,
  • P. Marquet

摘要

We present technological advances in Digital Holographic Microscopy (DHM) enabling the acquisition of quantitative phase signals virtually free of coherent noise. This is achieved through a polychromatic implementation (p-DHM) that combines multi-wavelength acquisition with advanced signal processing. The resulting high-fidelity phase data reveal subtle dynamic and structural cellular processes. When applied to patient-derived cells, this methodology enables the identification of disease-specific phenotypes, opening new perspectives for diagnostics, mechanistic insight, and drug screening.