Physician burnout has become increasingly prevalent. It is not only harmful to physicians’ health and well-being, but it also affects the quality and safety of patient care. Physician burnout is already recognized as a public health problem. Resilience research provides practical answers to the central question of the salutogenesis model—what keeps people healthy in the presence of stress? In order to prevent work-related exhaustion, basic personal needs must be satisfied as the basis of mental health and the empirically proven characteristics of a healthy work environment must also be present. Based on established findings on the development of burnout, this chapter presents practical options for designing a healthy work environment at a personal and organizational level as well as healthy resilience strategies. Work, which is characterized by mindfulness with a view to one’s own needs and what is personally feasible, itself becomes a health factor and the best means of preventing burnout.