Cases of burnout, compassion fatigue and mental health problems are increasing among healthcare workers with consequences that impact individual wellbeing, teamwork and the quality and safety of patient care. Registered healthcare professionals are deciding to leave soon after qualifying with the most commonly cited reason being work-related exhaustion and burnout. Recent reports highlight that even the most basic needs of healthcare workers are not being met, such as adequate rest, food and hydration. Fostering a workplace culture that enables and supports wellbeing practices can overcome the neglect that some individual workers face. In this chapter, a variety of issues are discussed, including the acceptability of restricting water bottles on wards to reduce cross-infection and how incidents or errors are investigated by healthcare organisations and professional bodies. Culture-based issues such as support for blame culture in healthcare and psychological fear in the workplace are discussed. Psychologically unsafe environments and blame-centred investigations into incidents contribute towards unmanageable stress and psychological harm for individuals, especially where this is compounded by unrelenting demands that do not prioritise the basic needs of individuals. This chapter highlights how workplace culture contributes towards individual exhaustion, compassion fatigue and burnout.