Numerous anthropogenic activities caused by rapid industrialization and urbanization release polycyclic aromatic hydrocarbons (PAHs) as toxic environmental pollutants. The PAHs come from unburnt combustion in residential and commercial properties, garbage burning and activities involving fossil fuels. The PAHs pollutants are widely distributed and equally present in the atmosphere, aquatic and terrestrial ecosystems. PAH pollutants directly and indirectly negatively impact human health, well-being, and biodiversity worldwide. The removal of PAHs is a global challenge because of their inherent characteristics, which make them long-lasting pollutants with a broad range of biological and chemical toxicity. The global challenges have been caused by adverse PAH effects, which prompted the remediation strategies that reduce the ecosystem’s long-term impact, confirm safety and decrease risks to humans and ecosystems. The sustainable treatment strategy remains challenging to implement for the remediation of PAH. More recently, various integrated advanced and multidisciplinary remediation techniques have been successfully used, including chemical, biological and physical approaches such as nanomaterial-based technologies, microbial bioremediation, electrokinetic and adsorption photocatalysis. Combining these techniques shows a comprehensive and long-term strategy to deal with the problems caused by PAH contamination. The current study primarily examines innovative and multidisciplinary approaches that integrate various techniques, which are becoming increasingly popular due to their promise of more effective remediation of PAH in ecological systems.