Reactive oxygen species are by-products of cellular metabolism and play a crucial role in cell signaling pathways, serving as secondary messengers that regulate various physiological processes in the immune response. Maintaining cellular homeostasis depends on an intricate balance between the production of reactive oxygen species and antioxidant defense mechanisms. Disruption in redox homeostasis and oxidative stress are key factors in inflammatory conditions, including diabetes, inflammatory bowel disease, chronic obstructive pulmonary disease, and osteoarthritis. Despite the fact that conventional anti-inflammatory medicines provide symptomatic relief, their prolonged use is prohibited due to severe side effects on multiple organs, including gastrointestinal and cardiovascular complications and renal failure. Therefore, Complementary and Alternative Medicine (CAM) therapies, such as herbal medicine, acupuncture, nutritional interventions (including probiotics and postbiotics) and mind–body therapies, introduce a novel method for controlling inflammation and oxidative stress. CAM aims to target inflammatory mediators and boost endogenous antioxidant systems to restore cellular redox balance and improve anti-inflammatory effects. This chapter explores the therapeutic potential of CAM modalities, combining current research to describe the mechanism of action and their role within an integrated healthcare model.