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Reactive oxygen species, or ROS, is a chemical made by cells during regular body functions. These chemicals can affect many things inside the cells, like inflammation and the growth of cancer. When there is a little or a moderate amount of ROS, it can help cells survive and trigger important signals in the body. But if there is too much ROS, it causes oxidative stress, which can hurt DNA, cause inflammation, and lead to cancer. This chapter looks closely at how ROS is made in normal cells and how it affects inflammation and cancer. It also explains how ROS influences different types of immune cells. This chapter explores how ROS interacts with the body’s immune system in cancer and how it affects treatments like immune checkpoint inhibitors, CAR-T cells, and cancer vaccines.

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ROS-Mediated Inflammation in Cancer Cell and Tumor Microenvironment

  • 章节

  • 发表日期：

    2026年

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  • Aganta Chakraborty,
  • Sanket Pramanik,
  • Shrabasti Mullick,
  • Mohini Mondal,
  • Biplab Debnath,
  • Debajit Dewan,
  • Sumel Ashique,
  • Farzad Taghizadeh-Hesary

摘要

Reactive oxygen species, or ROS, is a chemical made by cells during regular body functions. These chemicals can affect many things inside the cells, like inflammation and the growth of cancer. When there is a little or a moderate amount of ROS, it can help cells survive and trigger important signals in the body. But if there is too much ROS, it causes oxidative stress, which can hurt DNA, cause inflammation, and lead to cancer. This chapter looks closely at how ROS is made in normal cells and how it affects inflammation and cancer. It also explains how ROS influences different types of immune cells. This chapter explores how ROS interacts with the body’s immune system in cancer and how it affects treatments like immune checkpoint inhibitors, CAR-T cells, and cancer vaccines.