Global challenges such as environmental pollution, resource depletion, climate change, and loss of biodiversity, compounded by issues prevalent in third-world countries like overcrowded urban spaces and public health disparities, demand innovative, sustainable solutions. In response, this paper explores the integration of nature-inspired design and sustainability principles into interdisciplinary design education. The primary objectives are to develop an education framework that embeds these principles, fosters collaborative learning across disciplines, and equips students with the skills necessary to address both global and local sustainability challenges. As an initial approach subject of “Materials Exploration” is reframed using a workshop model based on Kolb’s experiential learning theory, emphasizing systems thinking and ecological impact. This model demonstrates how content can be transformed to foster a deeper understanding of nature-inspired principles and sustainable practices. The outcomes of this approach will guide the broader restructuring of design curricula, categorizing subjects according to their potential for sustainability integration. This paper thereby argues that interdisciplinary design education, with the core of biomimicry and sustainability, can produce a generation of designers capable of addressing contemporary global challenges through innovative, ethical, and sustainable solutions.