Chapter 5 addresses the practical challenges and opportunities associated with incorporating cannabinoids into food products. It examines available cannabinoid sources, from hemp seeds to concentrated extracts, and their suitability for food applications. The interaction between cannabinoids and different food matrices is also explored, with particular attention to stability during processing and storage. Strategies to enhance cannabinoid solubility and bioavailability—such as co-administration with excipient foods and the use of lipid-based delivery systems—are discussed in light of current scientific evidence. The chapter also considers public health concerns and the evolving regulatory landscape governing cannabinoid-containing foods. Concluding with future perspectives, this chapter provides a forward-looking framework for the safe, effective, and innovative development of cannabinoid-enriched food products, bridging science, technology, and regulation.