Cranio-maxillofacial (CMF) trauma encompasses a complex spectrum of injuries affecting the facial skeleton. These injuries involve fractures of the mandible, maxilla, zygomaticomaxillary complex, orbital floor, and frontal bone, each presenting unique diagnostic and therapeutic challenges due to anatomical intricacy and variability. This chapter provides a comprehensive overview of CMF fracture types, including classification systems and radiographic hallmarks, Selected approaches are presented to demonstrate how AI tools support clinicians in the detection of fractures, and reduce diagnostic errors. By integrating clinical insights with AI-driven methodologies, this chapter underscores the potential of AI in acute trauma settings and lays the groundwork for future developments in precision maxillofacial surgery.