This paper presents the design of Microstrip patch antenna with indirect gap coupled feed mechanism for wearable applications. Initially, the inset fed microstrip patch antenna was designed and optimized for free space applications and evaluated for its performance. Further, the design is modified with the gap-coupled feed to enhance its bandwidth, return loss and radiation properties. Finally, to utilize the proposed antenna for wearable applications, the antenna was again optimized by considering it to be placed on the human body model that consists of different layers such as skin, muscle and bone. It is observed that the bandwidth of the final proposed antenna is enhanced from 60 MHz to 710 MHz Also, the appreciable S11 value of −30 dB is observed at the desired resonant frequency of 2.4 GHz with better radiation properties. The proposed antenna is able to achieve 1.15 dB of radiation gain and exhibits 30% radiation efficiency when placed over the considered human body model. Thus, the designed antenna justifies its utilization for wearable and healthcare monitoring applications.