Environmental contamination that is caused by heavy metalsHeavy metal and organic contaminants poses a threat to the global sustainabilitySustainability of human health and also ecosystemsEcosystem. Typical methods for remediation often fail since they are inefficient and costly. These methods also impact the environmentEnvironment in secondary ways like physical filtration and chemical precipitation. Revolutionary genomics presents a ground-breaking method using natural microbialMicrobial detoxification abilities of microorganisms now. Modern genomic strategies together with tacklingTackling strategies heavy metalHeavy metal and organic pollutantOrganic pollutant contamination will be highlighted within this chapter. Key microbial genes that are responsible for pollutant uptake sequestration and degradationDegradation have been identified and modified through the recent advancements in metagenomics synthetic biology and CRISPR-based gene editing. By engineering microbes, we can develop within highly efficient bioremediation systems having improved metabolic pathways able to break down toxic compounds also immobilizing hazardous metals. Besides, microbial consortia are applied, and horizontal gene transfer occurs, easing synergistic interactions between species. Diverse conditions benefit from these bioremediation-optimizing interactions. Omics technologies such as transcriptomics and proteomics give valuable perceptions into microbialMicrobial stress responses therefore researchers can design more strong and adaptive strains. Revolutionary strategies are highlighted by this chapter so as to set the stage for a stable pollution-free future from heavy metalsHeavy metal together with organic pollutantsOrganic pollutant through sustainable environmental practices with microbial genomicsMicrobial genomics, minimizing ecological damage plus ensuring long-term environmental resilience.