The Nordic countries are like the rest of the world largely affected by the processes brought about by human impacts on the Earth. However, the speed of climate change in the Arctic is several times as fast as in the rest of the world, a phenomenon known as Arctic amplification (Rantanen et al. in Commun Earth Environ 3:1–10, 2022). Thus, climate change in the Arctic is not just having an impact on the Nordic region, but it also acts as a driver for conditions in the rest of the globe. This makes the Nordic North of particular interest to the whole global society. Among the most important changes detected here are declines in nature, directly driven by land and sea use (change, intensification); direct exploitation of resources (especially fishing and mining); pollution; the expansion of invasive species; the effects of globalization and its various economic components; geopolitical tensions; and other significant processes worthy of consideration. This chapter summarizes the rapid development of the One Health approach in addressing the specific challenges posed by climate change and zoonotic diseases in the Nordic region. It highlights collaborative efforts among Nordic countries, including Arctic Six cooperation, and other major regional funding efforts at research and education. It discusses how the utilization of One Health principles can address the needs of the region and noted the importance of interdisciplinary collaboration in achieving identified goals. Also, it discusses the specific health challenges posed by environmental contaminants, the transmission of zoonotic diseases, and the impact of climate change on species distribution that are seen in the Nordic North. It also considers the role of citizen science in data collection and the need for international collaboration in addressing these complex issues. Overall, the chapter underscores the urgency of addressing environmental and health challenges in this area through evidence-based policymaking and community engagement in the Nordic region.