The chapter highlights how neuroscience increasingly informs our understanding of architecture’s influence on behavior and social relationships. While research has examined architectural effects on memory, emotion, pre-reflective reactions, and cognition, it often overlooks biographical, cultural, and genetic dimensions of human memory. Addressing this gap requires exploring how first-person perception-the phenomenology of lived experience-interacts with neuroscientific and environmental psychology findings. Desire functions as a conceptual bridge, linking emotional memory to embodied engagement with architecture. As affective components of perceptual loops, desires are projected outward while shaped by spatial interaction. Revisiting evolutionary origins of body-space interaction elucidates the fundamental processes underlying these relationships,