Religious cognitions and behaviors effectively deal with stressful events. Religious involvement may promote better health by enhancing feelings of self-esteem, efficacy, or perception of control; promoting constructive coping; and enhancing social support. Participation in religious communities may promote mental and physical well-being by regulating health-related behaviors. Spirituality such as praying for others is a source of social support. Religion/spirituality is associated with reduced depression and anxiety, and increased longevity. Religion/spirituality may give depressed patients with physical diseases a sense of purpose and meaning in life despite their health problems. Meaning-centered group psychotherapy may help patients with advanced cancer search for meaning and purpose and enhance a sense of peace in their lives. Clinicians can play a crucial role in spiritual assessment and making pastoral care referrals.