Breast cancer patients with persistent concerns regarding body image, sexual desire, and sexual function should be referred to professionals. Clinicians should be conscious of the possibility that antidepressant efficacy will be lower in women taking an estrogen antagonist, such as tamoxifen. The quality of life in prostate cancer patients needs to be emphasized because treatments not only provide a good survival rate but also cause adverse side effects. Prostate cancer patients need support in psychological, informational, and daily living domains. A variety of antidepressants can be used in depressed patients with breast or prostate cancer.