There is a growing adoption of minimally-invasive liver resection (MILR) with reported improvements in perioperative outcomes. The utility of MILR in the setting of liver resections requiring modulation of the future liver remnant (FLR) such as two-stage hepatectomy (TSH) and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has garnered considerable interest, although substantial concerns over its safety profile remains. This chapter examines the evidence for MILR in TSH and ALPPS thus far, and highlights areas of ongoing endeavors in pushing the frontiers of minimal-invasiveness in liver regeneration.