With increasing climate variability, combining climate-smart practices with regenerative agriculture will be one of the key paths to sustainable development. This chapter explores the relationships among soil, water, and innovation and develops a broader framework for climate-resilient and resource-efficient food systems in South Asia and elsewhere. This chapter starts with soil–water relationships and demonstrates how soil structure, porosity, and organic matter play a role in plant health, water retention, and carbon cycling. This part also shows how regenerative practices, many of which rely heavily on organic matter through practices such as mulching, cover cropping, and conservation tillage, can improve moisture availability and thereby contribute to the hydrological functioning of soil. The innovative irrigation practices evaluated, including AWD, ZT-DSR, and microirrigation systems, all have the potential to decrease the water footprint and improve nutrient-use efficiency. Knowledge of indigenous water management and farmer-led innovations are discussed in this context. This chapter provides analytical tools for quantifying inputs from irrigation and water use efficiency, decision-support systems, and digital monitoring platforms that utilize IoT-based sensors and remote sensing applications to provide real-time decisions on water application. This study also highlights the importance of understanding the water–energy–nutrient nexus and how water use is an important pathway to GHG emissions and nutrient leaching, which are critical conditions for preserving ecosystem services. Climate-smart irrigation practices will supplement food system resilience against rainfall uncertainty while simultaneously and potentially supporting soil carbon sequestration. This section discusses the socioeconomic and institutional factors driving adoption and practice change and provides examples of community-based water governance and participatory initiatives as a framework for building capacity in water governance. Emerging research priorities relate to automation, real-time systems with data integration, and long-term monitoring of ecosystems. This study concludes with general recommendations from a policy perspective and options for scaling, which provide better pathways for deploying soil–water innovations that are driven by farmers and science-based.