The Body-in-White (BiW) is the structural part of the chassis that connects to the wheels, via the suspension, and carries the passengers, the goods, and the engine. The BiW, as a flexible component, also plays an active role in the vehicle handling and ride behavior. This work aims to shed some light on the impact of the flexibility of the BiW in the handling behavior of road vehicles by correlating the vehicle response to the deformation of the BiW. Flexible multibody models are used to study the handling behavior of a road vehicle considering different materials for the BiW: rigid; steel; and aluminum. The three corresponding models are compared in terms of their contribution to the vehicle dynamics by studying the vehicle response during the sine with dwell maneuver, defined in the standards and used by the industry to characterize the vehicle handling and active safety. The results suggest that the effect of the BiW to the sine with dwell response is significant. The differences between the different designs are mainly caused by changes in wheel-load transfer and side-slip angles of the tires, due to elastic deformation of the BiW.