Scholarlink

The uterus and cervix are dynamic, mechanically active organs that play central roles in reproductive function and disease. This chapter provides a comprehensive overview of the fundamental biomechanical principles and experimental methodologies used to characterize their material behavior across length scales, including compression, tension, indentation, and shear. A detailed synthesis of ex vivo mechanical properties measured for the human uterus and cervix in nonpregnant and pregnant states is presented, describing parameters of stiffness, strength, extensibility, and time dependence. This chapter further highlights notable obstetric and gynecologic disorders affecting the uterus and/or cervix in which mechanical factors are either characteristic features of the disease or implicated in its pathogenesis. This chapter concludes by outlining future research directions and underscoring the importance of biomechanical insights in guiding the design of biomaterials for therapeutic and investigative applications applied to reproductive health.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Biomechanics of the Uterus and Cervix Across Pregnancy and Disease: Considerations for Biomaterial Design

  • 章节

  • 发表日期：

    2026年

查看全文
  • Erin M. Louwagie,
  • Daniella M. Fodera

摘要

The uterus and cervix are dynamic, mechanically active organs that play central roles in reproductive function and disease. This chapter provides a comprehensive overview of the fundamental biomechanical principles and experimental methodologies used to characterize their material behavior across length scales, including compression, tension, indentation, and shear. A detailed synthesis of ex vivo mechanical properties measured for the human uterus and cervix in nonpregnant and pregnant states is presented, describing parameters of stiffness, strength, extensibility, and time dependence. This chapter further highlights notable obstetric and gynecologic disorders affecting the uterus and/or cervix in which mechanical factors are either characteristic features of the disease or implicated in its pathogenesis. This chapter concludes by outlining future research directions and underscoring the importance of biomechanical insights in guiding the design of biomaterials for therapeutic and investigative applications applied to reproductive health.