Reproductive tissue engineering is a powerful approach for developing advanced in vitro research platforms and regenerative therapies. Yet, replicating native tissue structure and function remains a major challenge, as it requires integrating complex architectures and biophysical cues that are difficult to produce with manual fabrication methods. Bioprinting comprises a variety of technologies to direct tissue assembly, enabling control over the tissue architecture and cellular microenvironment. Here, we review recent bioprinting applications in reproductive tissue engineering, which are still early stage and focused on constructing implantable regenerative scaffolds or modeling tumor progression in vitro. We also highlight opportunities to bioprint architecturally complex, functional tissues to serve as next-generation in vitro models and cell-based therapies. Coupled with innovations in organoids and biomaterials, bioprinting can accelerate reproductive tissue engineering and broaden both experimental and therapeutic applications.

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Advancing Reproductive Tissue Engineering with Bioprinting

  • Pei Wen Xiao,
  • Kayla J. Wolf

摘要

Reproductive tissue engineering is a powerful approach for developing advanced in vitro research platforms and regenerative therapies. Yet, replicating native tissue structure and function remains a major challenge, as it requires integrating complex architectures and biophysical cues that are difficult to produce with manual fabrication methods. Bioprinting comprises a variety of technologies to direct tissue assembly, enabling control over the tissue architecture and cellular microenvironment. Here, we review recent bioprinting applications in reproductive tissue engineering, which are still early stage and focused on constructing implantable regenerative scaffolds or modeling tumor progression in vitro. We also highlight opportunities to bioprint architecturally complex, functional tissues to serve as next-generation in vitro models and cell-based therapies. Coupled with innovations in organoids and biomaterials, bioprinting can accelerate reproductive tissue engineering and broaden both experimental and therapeutic applications.