The placenta is often considered a “waste” material after birth, yet it contains a variety of factors important for regenerative medicine, many of which have been used as biomaterials to support wound repair. Herein, we discuss the placenta structure and components, processing the placenta for regenerative medicine approaches, biomaterials applications of the placenta, placenta-derived stem cells and factors in biomaterials, and clinical applications of placentas. Specifically, we focus on the amniotic membrane, chorionic membrane, and placental disc layers in our chapter. This chapter aims to discuss similarities and differences between placental layers used in biomaterial applications, and current methods for using the placenta as a biomaterial for wound repair. We contrast the placenta layer biological components, mechanical properties, cell types, processing procedures, and differences in wound healing outcomes. Universally, the placenta provides an immunomodulatory material rich in factors that can prevent chronic inflammation. We also examine factors of the placenta, such as soluble factors, cells, and extracellular vesicles, which can be used separately from biomaterials as factors for repair. Finally, we discuss companies and biomaterial products made from the placenta, which are used clinically for wound healing applications. This chapter highlights the recent advances in biomaterials made from the placenta and the importance of which layer of the placenta is used for repair.