Automotive electrification and smart driving technologies open up new opportunities to reduce brake wear and ambient air pollution. Cooperative brake control algorithms will improve energy recovery with high deceleration rates. The vehicle system calibration in turn has an increasingly high impact on the mechanical usage variability of the brake system. Design loads of the brake system and consequently weight and cost heavily depend on vehicle calibration. It is necessary to understand actual vehicle usage on public roads by different customer groups over the full life cycle of a vehicle. This study describes a concept called VTM (virtual test market), which is promising a cost-efficient, time-saving approach to tackle these challenges and which leads to accurate predictions. The VTM is based on a combination of aspects such as topography, traffic density, and market-specific driving behaviors. It includes a virtual vehicle and environment model, combined with real or virtual brake system components in the loop. This provides a versatile framework to test the comprehensive interaction between the virtual vehicle environment, vehicle dynamics, electro-hydraulics, and software effects for durability and reliability.