In order to solve the problems that the traditional numerical simulation method is not convergent when sliding in large deformation landslide, the influence of various factors on the mechanical properties of pipeline and the sensitivity are unclear. In the field of pipeline landslide, the coupled Euler-Lagrange method is introduced for the first time to establish a three-dimensional finite element model of pipeline traversing landslide. The mechanical response of pipeline under the sliding condition of pipeline operating pressure, diameter to thickness ratio, buried depth, soil cohesion and landslide area width is analyzed, and the sensitivity of pipeline is analyzed by orthogonal experiment. The results show that the coupled Euler-Lagrange method can be used to calculate the mechanical response of the landslide pipeline under large deformation. The relation of sensitivity of each factor to pipeline mechanics is as follows: landslide width > soil cohesion > buried depth > internal pressure > diameter to thickness ratio. The safety of the pipeline can be ensured by reducing the buried depth and controlling the internal pressure, and the safety of the pipeline can be ensured by avoiding passing through the hidden areas of large landslides and appropriately increasing the diameter thickness ratio of the pipeline.