Long-span hybrid composite beam single-pylon cable-stayed bridges are widely used in current bridge construction projects. The composite beams are mostly π-shaped laminated beam sections, and there is limited research on the vortex-induced vibration (VIV) performance of hybrid composite beam single-pylon cable-stayed bridges. This paper adopts computational fluid dynamics (CFD) simulation to analyze the vortex-induced vibration performance of the bridge, relying on an actual bridge. By obtaining the dynamic characteristics of the bridge through ANSYS, the study completes the vortex-induced vibration performance analysis of both the composite beam sections and the concrete beam sections, and examines the impact of the damping ratio on the vortex-induced vibration performance of the composite beam sections, providing references for bridge design and construction.