The preservation of European existing building stock needs to face to main aspects: that of structural integrity and that of energetic sustainability. In recent years the scientific community is making efforts to explore integrated seismic and energy retrofitting techniques, combining into a single assessment, aiming at simultaneous benefits also pointing to a more sustainable design. The paper explores the implementation of novel integrated seismic and energy rehabilitation techniques, based upon the concept of tuned mass damper (TMD). Three different structural solutions are proposed to implement the TMD concept on an existing building: non- conventional TMD, large mass TMD and tuned mass damper inerter (TMDI), while three different solutions are evaluated towards retrofitting the building envelope: photovoltaic panels on the roof, thermochromic painting on outer surfaces, and the construction of a green roof system. The integrated interventions are implemented on the building roof, which can be disconnected and isolated from the substructure, or rebuilt and isolated from the substructure, adding improved energy performances. The methodology is exemplified on a case study of reinforced concrete residential building constructed around the 1960s–1970s in three different climatic and seismic areas of the Mediterranean located in Spain, Italy and Greece. Several sets of simulations were run in order to evaluate seismic and energy performances of the refurbished buildings. The integrated interventions are applied to the case studies and the results and performances are evaluated in terms of multi-objective analysis, from engineering point of views.