Burnout in medicine has become an all-too-common and serious challenge for healthcare providers. It goes beyond simple fatigue—it is a state of emotional exhaustion, a sense of detachment or depersonalization from patients, and a feeling of diminished personal accomplishment. This chapter explores what burnout is, how to recognize it in yourself or in colleagues, and how to respond effectively. You’ll also learn about moral injury—what it means in the healthcare setting and why understanding it matters. Burnout can strike at any stage of your career: as a medical student, physician assistant, resident, or even after decades in practice. That’s why it’s vital to identify the warning signs early and take action. Here, we share strategies to combat burnout, rebuild connection with patients, and create a healthier, more sustainable practice—so you can rediscover the joy that first drew you to medicine.