This chapter provides an extensive overview of cardiac pharmacology relevant to anaesthesia and critical care practice. It begins with a detailed examination of anti-arrhythmic drugs, discussing their classification, mechanisms of action, and clinical applications, particularly in the management of perioperative arrhythmias. Special attention is given to key agents such as amiodarone, adenosine, beta-blockers, and digoxin. The chapter continues with a thorough exploration of antihypertensive drugs, highlighting their roles in managing acute and chronic hypertension through mechanisms affecting vascular tone, cardiac output, and central sympathetic outflow. Classes covered include vasodilators, alpha-blockers, beta-blockers, calcium channel blockers, and centrally acting agents. Lastly, the chapter reviews vasopressors and inotropes, including noradrenaline, adrenaline, phenylephrine, vasopressin, dobutamine, and milrinone, with emphasis on their receptor profiles, haemodynamic effects, and perioperative considerations. By integrating pharmacological theory with practical clinical scenarios, this chapter equips trainees with essential knowledge for safe and effective cardiovascular management in dynamic clinical environments.